Document Type : Original Article
Assistant Professor of Plastic & Reconstructive Surgery, Department of Surgery, School of Medicine, Emam Khomeini Hospital, Ilam University of Medical sciences, Ilam, Iran
Master of Health Education, Research Expert, Clinical Research Development Unit, Emam Khomeini Hospital, Ilam University of Medical Sciences, Ilam, Iran USERN Office, Lorestan University of Medical Sciences, Khorramabad, Iran
Neurosurgery student, Tabriz University of Medical Sciences, Tabriz, Iran
Medical student of lSLAMIC Azad University, Tehran Medical Branch, Tehran, Iran
1. Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran 2. USERN Office, Lorestan University of Medical Sciences, Khorramabad, Iran
Introduction: In recent years, platelet-rich plasma has been used in burn wound repair, plastic surgery, bone and tendon ligament injury repair and other treatment at home and abroad. In Platelet-Rich Plasma, the concentrated platelets of the patient's blood are used, which will lead to collagen production, production and regeneration of new cells in the damaged skin. Due to the many complications of burn wounds and response to treatment in a long period of time; It is possible that the PRP method is effective in the treatment of burn wounds and restores the skin with minimal scarring in a shorter period of time. Therefore, the aim of this study was the effect of human platelet-rich plasma on hospitalized burn patients.
Methods: This is a clinical trial study that was conducted on burn patients admitted to Emam Khomeini Hospital in Ilam city in 2018. In this study, due to the fact that the time period was determined and all the patients who met the conditions for entering the study were treated after obtaining informed consent, the sample size formula was not used. Based on patient referrals and during a period of 6 months, 25 people suffered burns, according to the inclusion criteria; 20 people were included in the study. According to different wounds in patients; In each patient, routine treatment was used in one part of the wound and PRP in the other part of the wound in addition to the usual treatment. Then, they were compared in terms of the duration of epithelialized tissue formation in the burn site.
Results: using PRP along with routine treatment compared to routine treatment alone, the time to create epithelialized tissue is reduced by about 29%. It was also shown that the variables of age, gender, weight, height, burn mechanism, percentage of burn, amount of platelets and white blood cells have no significant relationship (p<0.05) with the effect of PRP in the treatment of burn patients.
Conclusion: The use of PRP along with the routine treatment of burn patients brought positive results, which can become a routine method in all burn departments if expanded, and widely reduce the length of hospitalization of patients and the amount of costs incurred by patients and Also, reducing the costs of the health system is effective.