The Role of Human Platelet-rich Plasma in Burn Injury Patients: A Single Center Study

Document Type : Original Article


1 Assistant Professor of Plastic & Reconstructive Surgery, Department of Surgery, School of Medicine, Emam Khomeini Hospital, Ilam University of Medical sciences, Ilam, Iran

2 Master of Health Education, Research Expert, Clinical Research Development Unit, Emam Khomeini Hospital, Ilam University of Medical Sciences, Ilam, Iran USERN Office, Lorestan University of Medical Sciences, Khorramabad, Iran

3 Neurosurgery student, Tabriz University of Medical Sciences, Tabriz, Iran

4 Medical student of lSLAMIC Azad University, Tehran Medical Branch, Tehran, Iran

5 1. Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran 2. USERN Office, Lorestan University of Medical Sciences, Khorramabad, Iran


Introduction: In recent years, platelet-rich plasma has been used in burn wound repair, plastic surgery, bone and tendon ligament injury repair and other treatment at home and abroad. In Platelet-Rich Plasma, the concentrated platelets of the patient's blood are used, which will lead to collagen production, production and regeneration of new cells in the damaged skin. Due to the many complications of burn wounds and response to treatment in a long period of time; It is possible that the PRP method is effective in the treatment of burn wounds and restores the skin with minimal scarring in a shorter period of time. Therefore, the aim of this study was the effect of human platelet-rich plasma on hospitalized burn patients.
Methods: This is a clinical trial study that was conducted on burn patients admitted to Emam Khomeini Hospital in Ilam city in 2018. In this study, due to the fact that the time period was determined and all the patients who met the conditions for entering the study were treated after obtaining informed consent, the sample size formula was not used. Based on patient referrals and during a period of 6 months, 25 people suffered burns, according to the inclusion criteria; 20 people were included in the study. According to different wounds in patients; In each patient, routine treatment was used in one part of the wound and PRP in the other part of the wound in addition to the usual treatment. Then, they were compared in terms of the duration of epithelialized tissue formation in the burn site.
Results: using PRP along with routine treatment compared to routine treatment alone, the time to create epithelialized tissue is reduced by about 29%. It was also shown that the variables of age, gender, weight, height, burn mechanism, percentage of burn, amount of platelets and white blood cells have no significant relationship (p<0.05) with the effect of PRP in the treatment of burn patients.
Conclusion: The use of PRP along with the routine treatment of burn patients brought positive results, which can become a routine method in all burn departments if expanded, and widely reduce the length of hospitalization of patients and the amount of costs incurred by patients and Also, reducing the costs of the health system is effective.


Main Subjects

  1. Servatyari K, Hamzehpour H, Rasouli M. The Prevalence and Types of Burn Wound Infection in the Burn Ward of Tohid Hospital in Sanandaj in 2015: A Short Report. JRUMS 2018; 16 (9) :883-890.
  2. Azimi L, Motevallian A, Ebrahimzadeh Namvar A, Asghari B, Lari AR. Nosocomial infections in burned patients in Motahari Hospital, Tehran, Iran. Dermatol Res Pract2011; Article ID 436952: 4 pages.
  3. Saberi M, Fatemi MJ, Soroush MR, Masoumi M, Niazi M. Burn Epidemiology In Iran: A Meta-Analysis Study. Iranian Journal of Surgery. 2016;24(1):47-61.
  4. Sheibani M, Karimi Mobarake M, Karimifard H. Survey of Platelet-Riched Plasma Injection with and without Calcium Gluconate in Treatment of Patients with Knee Osteoarthritis. Iranian Journal of Orthopedic Surgery. 2021;19(1):46.52. doi: 10.22034/ijos.2021.284046.1001.
  5. Amirnia M, Khodaeeiani E, Ahmadi D, Afshari N. Effect of Platelet-Rich Plasma (PRP) in the treatment of patients with androgenic alopecia. Medical Journal of Tabriz University of Medical Sciences. 2020;42(4):381-5.
  6. Khatu SS, More YE, Gokhale NR. Platelet-rich plasma in androgenic alopecia: myth or an effective tool. J Cutan Aesthet Surg 2014; 7:107-10.
  7. Navarro M, Asín M, Martínez M. Management of androgenetic alopecia: a comparative clinical study between plasma rich in growth factors and topical minoxidil. Eur J Plast Surg 2016; 39:173-80.

8.Pallua N, Wolter T, Markowicz M: Platelet-rich plasma in burns. Burns, 2010; 36(1): 4–8.

  1. Knighton DR, Ciresi K, Fiegel VD et al: Stimulation of repair in chronic, nonhealing, cutaneous ulcers using platelet-derived wound healing formula. Surg Gynecol Obstet, 1990; 170(1): 56–60.
  2. Huang H, Sun X, Zhao Y. Platelet-rich plasma for the treatment of burn wounds: A meta-analysis of randomized controlled trials. Transfusion and Apheresis Science. 2021;60(1):102964.
  3. Knighton DR, Ciresi KF, Fiegel VD, Austin LL, Butler EL. Classification and treatment of chronic nonhealing wounds. Successful treatment with autologous plateletderived wound healing factors (PDWHF). Ann Surg 1986;204(3):322–30.
  4. Ganio C, Tenewitz FE, Wilson RC, Moyles BG. The treatment of chronic nonhealing wounds using autologous plateletderived growth factors. J Foot Ankle Surg 1993;32(3):263–8.
  5. Kazakos K, Lyras DN, Verettas D, Tilkeridis K, Tryfonidis M. The use of autologous PRP gel as an aid in the management of acute trauma wounds. Injury 2008;
  6. Henderson JL, Cupp CL, Ross EV, Shick PC, Keefe MA, Wester DC, et al. The effects of autologous platelet gel on wound healing. Ear Nose Throat J 2003;82(8):598–602.
  7. Kao YC, Lin DZ, Lee SL, Chen C, Wang HJ, Chiu WK. Assisted therapy with platelet-rich plasma for burn patients: A meta-analysis and systematic review. Burns.2021; 47(5):1012-1023. ‏

16.Mahdavi S, Falahi M. The effect of PRP on burn wounds: a review study. 8th International Burn Congress.2018