Evaluation of Red Cell Distribution Width Alterations with Severity of Migraine

Document Type : Original Article

Authors

1 Isfahan clinical toxicology research center, Isfahan university of medical sciences, Isfahan, Iran

2 clinical research development center, Najafabad branch, Islamic Azad University, Najafabad, Iran

3 Department of Biostatistics, School of Public Health & Health Sciences, University of Massachusetts, Amherst, MA, USA

4 Student research academy, school of medicine, Guilan University of medical sciences, Rasht, Iran

5 Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract

Introduction: Migraine is an inflammatory condition with high prevalence. Approximately 
18% of women and 6% of men suffer from Migraine. It is classified into two groups based on 
aura manifestations. Aura is characterized by any combination of visual, hemisensory, or language abnormalities. Although not completely elucidated, one possible explanation for its cause 
may be related to the reduction of blood flow of the brain’s arteries or increased hemoglobin 
level. In this study, we aim to find out the relationship between migraine and red cell distribution width (RDW). Methods: 100 patients with migraine who were referred to specialized 
clinics Al-Zahra hospital between 2015-2016 and age and sex-matched 100 control subjects 
enrolled in this study. The disease diagnosis was confirmed by a neurologist. Fasting venous 
blood samples were taken from subjects for performing CBC, ferritin and, iron, and TIBC tests. 
HIT6 questionnaire was considered to assess the severity of migraines. Results: There were 100 
patients with a median age of 36 years (range 18-50). 22% were male and 78% were female. 
Data analysis didn’t show any relationship between migraine severity and RDW. Also, RDW 
didn’t have any relationship with the type of migraine (with aura or without aura). Conclusion: 
This study could not reveal any significant association between RDW and migraine. Observing 
high RDW in both case and control groups brings us to the hypothesis high prevalence of iron 
deficiency in our country. According to the results, low ferritin levels had a relationship with 
increased severity of migraine.

Keywords

Main Subjects

References

  1. Lukacs M, Tajti J, Fulop F, Toldi J, Edvinsson L, Vecsei L. Migraine, neurogenic inflammation, drug development-pharmacochemical aspects. Current medicinal chemistry. 2017;24(33):3649-65.
  2. Conti P, D’Ovidio C, Conti C, Gallenga CE, Lauritano D, Caraffa A, et al. Progression in migraine: role of mast cells and pro-inflammatory and anti-inflammatory cytokines. European journal of pharmacology. 2018.
  3. Yücel M, Kotan D, Gurol Çiftçi G, Çiftçi I, Cikriklar H. Serum levels of endocan, claudin-5 and cytokines in migraine. Eur Rev Med Pharmacol Sci. 2016;20(5):930-6.
  4. Martami F, Jahromi SR, Togha M, Ghorbani Z, Seifishahpar M, Saidpour A. The serum level of inflammatory markers in chronic and episodic migraine: a case-control study. Neurological Sciences. 2018;39(10):1741-9.
  5. MacGregor EA. Migraine. Ann Intern Med. 2017;166(7):Itc49-itc64.
  6. Gryglas A, Smigiel R. Migraine and Stroke: What's the Link? What to Do? Curr Neurol Neurosci Rep. 2017;17(3):22.
  7. Ramachandran R. Neurogenic inflammation and its role in migraine. Semin Immunopathol. 2018;40(3):301-14.
  8. Celik A, Karayakali M, Altunkas F, Karaman K, Arisoy A, Ceyhan K, et al. Red cell distribution width is correlated with extensive coronary artery disease in patients with diabetes mellitus. Cardiovascular journal of Africa. 2017;28(5):319.
  9. Khani M, Karimi Z. Prognosis of Chronic Myeloid Lymphoma with Red Cell Distribution Width. J Blood Res. 2018;1(1):5.
  10. Öztürk ZA, Ünal A, Yiğiter R, Yesil Y, Kuyumcu ME, Neyal M, et al. Is increased red cell distribution width (RDW) indicating the inflammation in Alzheimer's disease (AD)? Archives of gerontology and geriatrics. 2013;56(1):50-4.
  11. Zhang T, Li J, Lin Y, Yang H, Cao S. Association Between Red Blood Cell Distribution Width and All-cause Mortality in Chronic Kidney Disease Patients: A Systematic Review and Meta-analysis. Arch Med Res. 2017;48(4):378-85.
  12. Peng YF, Cao WY, Zhang Q, Chen D, Zhang ZX. Assessment of the Relationship Between Red Cell Distribution Width and Multiple Sclerosis. Medicine (Baltimore). 2015;94(29):e1182.
  13. Aktas G, Sit M, Dikbas O, Tekce BK, Savli H, Tekce H, et al. Could red cell distribution width be a marker in Hashimoto's thyroiditis? Exp Clin Endocrinol Diabetes. 2014;122(10):572-4.
  14. Goyal H, Lippi G, Altin Gjymishka BJ, Chhabra R, May E. Prognostic significance of red blood cell distribution width in gastrointestinal disorders. World journal of gastroenterology. 2017;23(27):4879.
  15. Zhang Z, Chew GM, Shikuma CM, Gangcuangco LMA, Souza SA, Shiramizu B, et al. Red blood cell distribution width as an easily measurable biomarker of persistent inflammation and T cell dysregulation in antiretrovirally treated HIV-infected adults. HIV clinical trials. 2018;19(5):172-6.
  16. Lippi G, Cervellin G, Mattiuzzi C. Migraine and erythrocyte biology: a review. International journal of laboratory hematology. 2014;36(6):591-7.
  17. Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G. Red blood cell distribution width: A simple parameter with multiple clinical applications. Critical reviews in clinical laboratory sciences. 2015;52(2):86-105.
  18. Pamuk GE, Top MŞ, Uyanık MŞ, Köker H, Akker M, Ak R, et al. Is iron-deficiency anemia associated with migraine? Is there a role for anxiety and depression? Wiener klinische Wochenschrift. 2016;128(8):576-80.
  19. Albury CL, Stuart S, Haupt LM, Griffiths LR. Ion channelopathies and migraine pathogenesis. Mol Genet Genomics. 2017;292(4):729-39.
  20. Palm-Meinders IH, Koppen H, Terwindt GM, Launer LJ, van Buchem MA, Ferrari MD, et al. Iron in deep brain nuclei in migraine? CAMERA follow-up MRI findings. Cephalalgia. 2017;37(8):795-800.
  21. The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629-808.
  22. Houts CR, McGinley JS, Wirth RJ, Cady R, Lipton RB. Reliability and validity of the 6-item Headache Impact Test in chronic migraine from the PROMISE-2 study. Quality of Life Research. 2021;30(3):931-43.
  23. Celikbilek A, Zararsiz G, Atalay T, Tanik N. Red cell distribution width in migraine. International journal of laboratory hematology. 2013;35(6):620-8.
  24. Arregui A, Leon‐Velarde F, Cabrera J, Paredes S, Vizcarra D, Umeres H. Migraine, polycythemia and chronic mountain sickness. Cephalalgia. 1994;14(5):339-41.
  25. Hermans H, Post MC, Thijs V, Spaepen M, Budts WI. Increased prevalence of migraine in adult congenital heart disease. Heart. 2007;93(3):361-2.
  26. Forcelini CM, Dantas DC, Luz C, Santin R, Stein AT, Barros HM, et al. Analysis of leukocytes in medication‐overuse headache, chronic migraine, and episodic migraine. Headache: The Journal of Head and Face Pain. 2011;51(8):1228-38.
  27. Stovner L, Hagen K, Waage A, Bjerve K. Hereditary haemochromatosis in two cousins with cluster headache. Cephalalgia. 2002;22(4):317-9.
  28. Gaul C, Krummernerl P, Tamke B, Kornhuber M. Chronic daily headache in hereditary hemochromatosis treated by venesection. Headache: The Journal of Head and Face Pain. 2007;47(6):926-8.
  29. Sevindik MS, Demirci S, Göksan B, Özge A, Savrun FK, Onur H, et al. Accompanying migrainous features in pediatric migraine patients with restless legs syndrome. Neurological Sciences. 2017;38(9):1677-81.
  30. Eidlitz-Markus T, Zolden S, Haimi-Cohen Y, Zeharia A. Comparison of comorbidities of migraine and tension headache in a pediatric headache clinic. Cephalalgia. 2017;37(12):1135-44.
  31. Calhoun AH, Gill N. Presenting a New, Non‐Hormonally Mediated Cyclic Headache in Women: End‐Menstrual Migraine. Headache: The Journal of Head and Face Pain. 2017;57(1):17-20.
Canon Journal of Medicine
Volume 3, Issue 1
March 2022
Pages 15-18

Files

History

  • Receive Date: 05 October 2021
  • Revise Date: 03 March 2021
  • Accept Date: 13 March 2022

Share

How to cite

Statistics