Document Type : Original Article
Isfahan clinical toxicology research center, Isfahan university of medical sciences, Isfahan, Iran
clinical research development center, Najafabad branch, Islamic Azad University, Najafabad, Iran
Department of Biostatistics, School of Public Health & Health Sciences, University of Massachusetts, Amherst, MA, USA
Student research academy, school of medicine, Guilan University of medical sciences, Rasht, Iran
Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Introduction: Migraine is an inflammatory condition with high prevalence. Approximately
18% of women and 6% of men suffer from Migraine. It is classified into two groups based on
aura manifestations. Aura is characterized by any combination of visual, hemisensory, or language abnormalities. Although not completely elucidated, one possible explanation for its cause
may be related to the reduction of blood flow of the brain’s arteries or increased hemoglobin
level. In this study, we aim to find out the relationship between migraine and red cell distribution width (RDW). Methods: 100 patients with migraine who were referred to specialized
clinics Al-Zahra hospital between 2015-2016 and age and sex-matched 100 control subjects
enrolled in this study. The disease diagnosis was confirmed by a neurologist. Fasting venous
blood samples were taken from subjects for performing CBC, ferritin and, iron, and TIBC tests.
HIT6 questionnaire was considered to assess the severity of migraines. Results: There were 100
patients with a median age of 36 years (range 18-50). 22% were male and 78% were female.
Data analysis didn’t show any relationship between migraine severity and RDW. Also, RDW
didn’t have any relationship with the type of migraine (with aura or without aura). Conclusion:
This study could not reveal any significant association between RDW and migraine. Observing
high RDW in both case and control groups brings us to the hypothesis high prevalence of iron
deficiency in our country. According to the results, low ferritin levels had a relationship with
increased severity of migraine.